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KMID : 1011820210620030340
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Investigative and Clinical Urology
2021 Volume.62 No. 3 p.340 ~ p.348
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Urinary microRNA-1913 to microRNA-3659 expression ratio as a non-invasive diagnostic biomarker for prostate cancer
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Byun Young-Joon
Piao Xuan-Mei
Jeong Pil-Du
Kang Ho-Won
Seo Sung-Phil
Moon Sung-Kwon
Lee Jong-Young
Choi Yung-Hyun
Lee Hee-Youn
Kim Won-Tae
Lee Sang-Cheol
Cha Eun-Jong
Yun Seok-Joong
Kim Wun-Jae
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Abstract
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Purpose: MicroRNAs (miRNAs) are small non-coding RNAs and are involved in the development, proliferation, and pathogenesis of prostate cancer (PCa). Urinary miRNAs are promising non-invasive biomarkers for PCa diagnosis because of their stability in urine. Here, we evaluated the diagnostic value of urinary miR-1913 to miR-3659 ratio in PCa patients and benign prostate hyperplasia (BPH) controls.
Materials and Methods: Candidate miRNAs were identified from urinary microarray data and tested by real-time PCR. The urinary miR-1913 to miR-3659 expression ratio was selected and tested in 83 urine samples (44 PCa and 39 BPH) to confirm its validity as a non-invasive diagnostic biomarker for PCa.
Results: The expression ratio of urinary miR-1913 to miR-3659 was significantly higher in PCa than in BPH (p=0.002) and showed a higher area under the receiver operating characteristic curve than prostate-specific antigen (PSA; 0.821 vs. 0.518) in patients within the PSA gray zone (tPSA: 3?10 ng/mL), with sensitivity of 75.0% and specificity of 78.6% (p=0.003).
Conclusions: The urinary miR-1913 to miR-3659 expression ratio was increased in PCa and may serve as a useful supplemental biomarker to PSA for the diagnosis of PCa, particularly in patients within the PSA gray zone.
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KEYWORD
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Biomarkers, Diagnosis, Gene expression, MicroRNA, Prostate neoplasms
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